B. E. Maryanoff,A. B. Reitz's Advances in Medicinal Chemistry: 4 PDF

By B. E. Maryanoff,A. B. Reitz

ISBN-10: 0444546499

ISBN-13: 9780444546494

ISBN-10: 0762300647

ISBN-13: 9780762300648

quantity four of Advances in Medicinal Chemistry is made from six chapters on quite a lot of issues in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic review, structure-activity correlation, and lead optimization. bankruptcy 1 offers an account approximately amino acid-based peptide mimetics comparable to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new aspects of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the hunt for brand spanking new medicinal drugs for the remedy of malaria in keeping with the common product artemisinin. bankruptcy four applies computational chemistry to the assessment of compound libraries for organic trying out. bankruptcy five describes the development of a third-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a way to discover the intermolecular contacts focused on agonist peptide attractiveness. ultimately, bankruptcy 6 describes the learn carried out at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz

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